Acetylcholine produces stimulus-specific receptive field alterations in cat auditory cortex.
نویسندگان
چکیده
Frequency receptive fields (RFs) were determined before and after pairing iontophoretic administration of acetylcholine (ACh) with a repeated single-frequency stimulus in the auditory cortex of barbiturate-anesthetized cats. In 58% of the cells, the paired ACh + tone treatment produced subsequent alterations of frequency RFs. In half of these cases, the RF modifications were highly specific to the frequency that had been paired with ACh. Atropine antagonized the frequency-specific effects of ACh, suggesting that they were mediated via muscarinic cholinergic receptors.
منابع مشابه
Cholinergic modulation of responses to single tones produces tone-specific receptive field alterations in cat auditory cortex.
Acetylcholine (ACh), acting via muscarinic receptors, is known to modulate neuronal responsiveness in primary sensory neocortex. The administration of ACh to cortical neurons facilitates or suppresses responses to sensory stimuli, and these effects can endure well beyond the period of ACh application. In the present study, we sought to determine whether ACh produces a general change in sensory ...
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عنوان ژورنال:
- Brain research
دوره 480 1-2 شماره
صفحات -
تاریخ انتشار 1989